By the 1560s, Spain's main policy in North America was to...

• discover new Indian kingdoms that could be conquered and exploited.
• prevent other European states from establishing bases there, which could threaten Spain's power.
• establish colonies of settlement along the Atlantic coast.
• control the fur trade of the North American interior. 

ANSWER: By the 1560s, Spain's main policy in North America was to prevent other European states from establishing bases there, which could threaten Spain's power.